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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
18/09/2018 |
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Data da última atualização: |
18/09/2018 |
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Autoria: |
FALCONER, J.; DAVIES, J. J.; ZHANG, H. P.; SMITH, R. |
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Título: |
Release of insulin-like growth factor I by the sheep placenta in vitro. |
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Ano de publicação: |
1991 |
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Fonte/Imprenta: |
Reproduction, Fertility and Development, v. 3, n. 4, p. 379-384, 1991. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: This study has utilized a tissue perifusion system to examine the release of insulin-like growth factor I (IGF I) from different regions of the sheep placenta at two stages of gestation. Placentae were obtained from ewes at either 116 +/- 7 (mean +/- s.e.) or 144 +/- 1.5 days of gestation and separated into the maternal basal plate or chorionic villous tissue. At both ages, the maternal basal plate tissue released approximately three times more IGF I than the chorionic villous tissue. No difference was found between the rate of release of IGF I from the maternal basal plate at 120 and 140 days of gestation, whereas the chorionic villous tissue released less IGF I later in gestation. Maternal basal plate tissue was less responsive to a depolarizing dose of KCl than was chorionic villous tissue at either age. After acid gel chromatography, perfusate from the basal plate had three peaks of IGF immunoreactivity (corresponding to binding protein, IGF I and a form with an intermediate molecular weight). In contrast, the chorionic villous tissue released only a form with a high molecular weight, corresponding to binding protein. These results demonstrate that the sheep placenta produced IGF I, that secretion varies between different placental zones which contain different cell types and that there are maturational changes in placental IGF I secretion. The IGFs may be involved in placental growth. |
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Palavras-Chave: |
Chorionic Villi; Perfusion; Placenta chemistry; Placenta secretion. |
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Thesaurus Nal: |
Ewes; Gestational age; Insulin-like growth factor I; Pregnancy; Sheep. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02145naa a2200265 a 4500
001 2095976
005 2018-09-18
008 1991 bl uuuu u00u1 u #d
100 1 $aFALCONER, J.
245 $aRelease of insulin-like growth factor I by the sheep placenta in vitro.
260 $c1991
520 $aAbstract: This study has utilized a tissue perifusion system to examine the release of insulin-like growth factor I (IGF I) from different regions of the sheep placenta at two stages of gestation. Placentae were obtained from ewes at either 116 +/- 7 (mean +/- s.e.) or 144 +/- 1.5 days of gestation and separated into the maternal basal plate or chorionic villous tissue. At both ages, the maternal basal plate tissue released approximately three times more IGF I than the chorionic villous tissue. No difference was found between the rate of release of IGF I from the maternal basal plate at 120 and 140 days of gestation, whereas the chorionic villous tissue released less IGF I later in gestation. Maternal basal plate tissue was less responsive to a depolarizing dose of KCl than was chorionic villous tissue at either age. After acid gel chromatography, perfusate from the basal plate had three peaks of IGF immunoreactivity (corresponding to binding protein, IGF I and a form with an intermediate molecular weight). In contrast, the chorionic villous tissue released only a form with a high molecular weight, corresponding to binding protein. These results demonstrate that the sheep placenta produced IGF I, that secretion varies between different placental zones which contain different cell types and that there are maturational changes in placental IGF I secretion. The IGFs may be involved in placental growth.
650 $aEwes
650 $aGestational age
650 $aInsulin-like growth factor I
650 $aPregnancy
650 $aSheep
653 $aChorionic Villi
653 $aPerfusion
653 $aPlacenta chemistry
653 $aPlacenta secretion
700 1 $aDAVIES, J. J.
700 1 $aZHANG, H. P.
700 1 $aSMITH, R.
773 $tReproduction, Fertility and Development$gv. 3, n. 4, p. 379-384, 1991.
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Embrapa Caprinos e Ovinos (CNPC) |
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| 1. |  | SIMÕES, B. F.; MAZUR, N.; CORREIA, M. E. F.; NIEMEYER, J. C.; MATOS, T. de S. Ecotoxicity test as an aid in the determination of copper guideline values in soils. Ciência Rural, Santa Maria, v. 50, n. 6, e20180961, 2020. Título em Português: Ensaios de ecotoxicidade como auxílio na determinação de valores orientadores de cobre em solos.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
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